Monday, June 15:

15:00-20:00 Registration

18:00-20:00 Welcome reception

Tuesday, June 16:

8:00-9:00 INRC/CPDD Plenary 1

Nora Volkow - Director, National Institute on Drug Abuse (NIDA)

9:00-10:00 Session 1 (Chair: Fred Nyberg, Uppsala University)

“Addiction to Prescription Opioids”

Thomas Clausen (University of Oslo)

Prescription opioid-abuse and dependence in Scandinavian Countries

Gabriele Fischer (Medical University of Vienna)

Addiction and diversion of prescription opioids in Europe

Pauline Voon (St. Paul's Hospital, Vancouver, CAN)

Nonmedical prescription opioid use in North America

10:00 – 10:15 Break

10:15 – 11:00 Hot Topics – Prescription Opioid Addiction

Naoko Kuzumaki (Toshi University, Tokyo)

Chronic pain and addiction

Paul Bigliardi (¹IMB/A*STAR, 8A Biomedical Grove, Singapore)

Clinical manifestations of opioids in skin

TBD

11:00-11:30 Discussion

11:30-13:30 Lunch & Even numbered posters (with CPDD)

13:30-14:45 Founders’ Lecture

Gavril Pasternak (Memorial Sloan-Kettering Cancer Center)
40 years on drugs: It’s all in the telling of the tail
14:45-15:00 Break

15:00-16:00 Session 2 (Chairs: Jay McLaughlin, Torrey Pines Institute for Molecular Studies; Jane Aldrich, University of Florida)

“Advances in Therapeutic Design - Opioid and Sigma Targets”

Chris McCurdy (University of Mississippi)

TBD

Andy Coop (University of Maryland)

UMB425: A Unique Opioid Analgesic with Lower Tolerance

Hank Mosberg (University of Michigan) Development of bifunctional MOR agonist/DOR antagonist peptides: Successes and failures

Jane Aldrich (University of Florida)

TBD

16:00 – 16:30 Hot Topics (TBD, 3 speakers)
16:30 - 17:00 Discussion

Wednesday, June 17:

8:00 - 08:30 INRC Plenary 1 - John Williams (Vollum Institute)

“What is all the confusion about opioid actions on dopamine neurons?”

8:30 – 9:00 Elyssa Margolis (UCSF)

9:00 – 9:30 MOP in the VTA

Kevin D. Wickman (University of Minnesota)

TBD

Adrianne R. Wilson-Poe (Columbia University)

Inflammatory pain dysregulates opioid function in the mesolimbic pathway

9:30 – 9:45 Discussion
9:45 - 10:00 Break

10:00 - 11:45 Session 3 (Chair: Frank Porreca, University of Arizona- Tucson)

“Pain and Reward”

Frank Porreca

TBD

Howard Fields (UCSF)

TBD

Catherine Cahill (UC-Irvine)

TBD

Siri Leknes (Oslo University Hospital)

TBD

11:45 - 12:00 Discussion

12:00 - 14:00 Lunch & Odd numbered posters (with CPDD)

14:00 - 16:00 INRC/CPDD Plenary 2 (Chair: Sandra Comer, Columbia University)

“Novel Strategies for Reducing Opioid Abuse”

Kathy Cunningham (University of Texas Medical Branch, Galveston)

TBD

Marco Pravetoni (University of Minnesota)

TBD

Jermaine Jones (Columbia University)

TBD

Ted Cicero (Washington University, St. Louis)

Epidemiology on the impact of opioid abuse-deterrent medications on opioid abuse in

the community

16:00 - 16:15 Break

16:15 - 17:00 Session 4 (Chair: Robert W. Gereau IV, Washington University-St. Louis)

“Optogenetics in Pain”

Robert W. Gereau IV (Washington University-St. Louis)

Fully-implantable wireless optoelectronic systems for interrogation of spinal and

peripheral pain circuitry

Anthony Pickering (University of Bristol)

Opto- and chemo-genetic activation of brainstem POMC neurones reveals opioid-

mediated analgesic and cardiorespiratory roles

Zhizhong Z. Pan (The University of Texas MD Anderson)

TBD

17:00 - 17:15 Discussion

Thursday, June 18:

8:00-10:00 INRC posters still up

8:00 - 9:00 Session 5 (Chair: Mary Jeanne Kreek, Rockefeller University)

“Vaccines to Prevent Drug Abuse”

Brian Reed (Rockefeller University)

Application of a novel small molecule vaccine platform to oxycodone immunization

Gary Matyas (Walter Reed Army Institute of Research)

Development and Optimization of a Heroin Vaccine

Paul Bremer (Scripps Research Institute)

Design of haptens and conjugate vaccines for heroin addiction

Joel Schlosburg (Scripps Research Institute)

Selectivity, capacity, durability: putting a heroin vaccine through its paces and clearing

the major hurdles towards clinical viability

9:00 – 9:30 Hot Topics - (TBD, 3 speakers)

9:30 – 9:45 Discussion

9:45 – 10:00 Break

10:00 – 12:00 INRC/CPDD Plenary 3 (Chair: Todd W. Vanderah, University of Arizona)

“Cannabinoid Mechanisms and Interventions”

Alexandros Makriyannis (Northeastern University)

TBD

Aron Lichtman (Virginia Commonwealth University)

Inhibition of the 2-AG biosynthetic enzyme diacylglycerol lipase beta: Antinociception

through a cannabinoid receptor independent pathway

Todd W. Vanderah (University of Arizona-Tucson)

TBD

Andrea Hohmann (Indiana University)

The Therapeutic Promise of Nonpsychoactive Cannabinoid Analgesics

12:00 - 13:00 Data Blitz + Lunch (Chair: Susan L. Ingram, Oregon Health and Science University)

13:00 - 14:00 Optional Early Career Event- Mock Study Section (Chair: José Moron-Concepción, Columbia University)

Friday, June 19:

8:00 - 9:15 Session 6 (Chair: Michael M. Morgan, Washington State University-Vancouver; Moderator: Tally M.

Largent-Milnes, University of Arizona)

“Opioid tolerance and Hyperalgesia (real consequences, treatment, mechanisms)”

Michael M. Morgan (Washington State University-Vancouver)

Why are there so many mechanisms of opioid tolerance?

Bradley K. Taylor (University of Kentucky)

TBD

Lori Eidson (Georgia State University)

Role of glia in opioid tolerance

Jürgen Sandkühler (Medical University of Vienna)

CNS mechanisms leading to opioid-induced Hyperalgesia

Dorit Pud (University of Haifa)

Opioids and abnormal pain perception in human